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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Machine Learning as a Tool for the Prediction of the Effect of Mutations on Protein Stability
 Dúbrava, Juraj Ondrej ; Martínek, Tomáš (referee) ; Musil, Miloš (advisor)
The main focus of this thesis is the prediction of the effect of amino acid substitutions on protein stability. My goal was to develop a predictive tool for the classification of the effect of mutations by combining several machine learning techniques. The implemented predictor, which utilizes SVM and Random forest methods, has achieved higher accuracy than any of the integrated methods. The novel predictive tool was compared with the existing ones using independent testing dataset. The predictor has yield 67 % accuracy and MCC 0,3.
Detailed record
Machine Learning as a Tool for the Prediction of the Effect of Mutations on Protein Stability
 Dúbrava, Juraj Ondrej ; Martínek, Tomáš (referee) ; Musil, Miloš (advisor)
The main focus of this thesis is the prediction of the effect of amino acid substitutions on protein stability. My goal was to develop a predictive tool for the classification of the effect of mutations by combining several machine learning techniques. The implemented predictor, which utilizes SVM and Random forest methods, has achieved higher accuracy than any of the integrated methods. The novel predictive tool was compared with the existing ones using independent testing dataset. The predictor has yield 67 % accuracy and MCC 0,3.
Detailed record

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